The Duetto Series 2 was introduced in 1969 and stayed in production until 1982. Of the four series made, this is the most long-lived spider. The design of the rear is due to aerodynamic requirements, as the Kammback was meant to reduce drag.

The engine could produce between 89 and 132 hp, depending on the size (throughout the years the options were 1,300, 1,600, 1,750, and 2,000 cc.) The 2,000 cc engine was adapted for the US market as well, though equipped with Spica indirect fuel injection due to the more rigid emission regulations.